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GUIDELINES & PROTOCOLS ADVISORY COMMITTEE warfarin Therapy - focussing During Invasive Procedures and Surgery effective confederation: October 1, 2010 Scope This guideline is directed towards those physicians confused in the man ripenment of warfarin therapy when the patient (19 years of age and over) begs invasive procedures and surgery. For patients younger than 19, extend to to the BC Childrens infirmary anticoagulation protocol. A summary (Appendix A) of this history in flowchart stage is included.

Therapeutic Measures for Reversal of warfarin Therapy: VitaminK Intravenous(IV)deliveryisthefastestandmost true(p)waytoobtaintheeffectofvitaminK Intramuscular(IM)orsubcutaneousdeliveryshouldbeavoided Iftheprocedureisin morethan24hours,thereisnodifferencebetween usingIVandoral(PO) Usefulforpost-operativeperiodsaswell overweening loony toonsofvitaminKcanleadtodifficultywithre-anticoagulation EffectonINRisobservedafter812hours,dependingonrouteofadministration Recommendeddoses: oral1to2mg IV5mgin50ccnormalsalineinfusedover30minutes VirallyInactivatedPlasma-Derived take down(Octaplex®) Useonlyinconsultationwithspecialist preferredproductforrapidreversalofwarfarinwhenavailable continuationofactionis~6hours,typicallyonlyonedoseisneeded Virallyinactivatedplasma-derivedconcentratecontainingfactorsII,VII,IX,XandProteinCand ProteinS essentialbeusedinconjunctionwithIVvitaminK IndicatedforimmediateINRreversalinpatients: withactive,seriousbleeding whorequiresurgerywithinnext6hours Containsheparinandiscontraindicatedin...If you sine qua non to get a full essay, order it on our website: Ordercustompaper.com

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